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SQI: Simpson Querry Institute

2022 News

Shana Kelley portrait

Kelley awarded Guggenheim Fellowship

April 18, 2022
SQI member Shana Kelley was one of three Northwestern University faculty members recently named a 2022 Guggenheim Fellow by the John Simon Guggenheim Memorial Foundation. With the fellowship, Kelley will develop a new class of sensors for the human body that will enable continuous monitoring of biochemical markers of health and disease.
SARS-CoV-2 spike protein

New COVID-19 nasal spray outperforms current antibody treatments in mice

April 14, 2022
A new protein-based antiviral nasal spray developed by SQI member Michael Jewett and colleagues at Northwestern University, University of Washington and Washington University at St. Louis is being advanced toward Phase I human clinical trials to treat COVID-19. Designed computationally and refined in the laboratory, the new protein therapies thwarted infection by interfering with the virus’ ability to enter cells. Notably, the top protein also neutralized all tested SARS-CoV-2 variants, something that many clinical antibodies have failed to do.
Macrophages and lymphatic cells

Lymphatics aid heart repair

April 5, 2022
Expression of a pro-lymphangiogenic growth factor after heart injury activates the lymphatic system, spurring leukocytes to help clear away dying cells, according to a study co-led by SQI member Guillermo Oliver and published in the Journal of Clinical Investigation. The findings cement the lymphatic system’s role in repair after heart attack and has both theoretical and practical therapeutic implications, the researchers said.
Press:

Mussels’ underwater glue inspires synthetic cement

March 15, 2022

Using a novel method to arrange molecules, researchers led by SQI member Nathan Gianneschi have created a material that outperforms the extraordinarily strong glue secreted by mussels. Their findings expand on how these protein-like polymers can be used as a platform to create new materials and therapeutics.

“The polymer could be used as an adhesive in a biomedical context, which means now you could stick it to a specific tissue in the body and keep other molecules nearby in one place, which would be useful in wound healing or repair,” Gianneschi said.

Evan Scott

Scott elected as AIMBE fellow

February 18, 2022
SQI member Evan Scott has been elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows, the AIMBE announced. Scott was cited for “outstanding contributions to understanding immunological processes contributing to diverse inflammation-driven pathologies, and for therapeutic approaches using biomaterial-based strategies.”
Lou Simpson

SQI remembers Lou Simpson

February 15, 2022
SQI leadership released a statement about the January 8 death of Lou Simpson, whose generous philanthropy has enabled the Institute's investigators to pursue innovative research in regenerative nanomedicine.

Tumors dramatically shrink with new approach to cell therapy

January 28, 2022

Researchers led by SQI member Shana Kelley have developed a new tool to harness immune cells from tumors to fight cancer rapidly and effectively.

Their findings, published in the journal Nature Biomedical Engineering, showed a dramatic shrinkage of tumors in mice compared to traditional cell therapy methods. With a novel microfluidic device that could be 3D printed, the team multiplied, sorted through and harvested hundreds of millions of cells, recovering 400% more of the tumor-eating cells than current approaches.

Guillermo Ameer

Ameer awarded the Technology Innovation and Development Award

January 26, 2022
SQI member Guillermo Ameer has received the 2022 Technology Innovation and Development Award, the Society For Biomaterials announced. The award recognizes an individual’s (or a team’s) successful application of basic and applied biomaterials research in the development of a novel medical product or technology that significantly benefits the health and well-being of patients.
ANTEC video trainings

ANTEC enhances training procedures during COVID-19 pandemic

January 20, 2022
Starting in the summer of 2020, the Analytical bioNanotechnology Equipment Core (ANTEC) overhauled its training procedures, enhancing hands-on guidance with a combination of illustrated, step-by-step user guides and detailed instructional videos. Ever since, the flexibility to provide either in-person or remote training has become a part of the core’s routine.
Nanotherapy for Type 1 diabetes

Nanotherapy offers new hope for the treatment of Type 1 diabetes

January 19, 2022
A team of researchers at Northwestern University led by SQI members Evan Scott and Guillermo Ameer has discovered a technique to help make immunomodulation more effective following islet transplantation. The findings could lead to a breakthrough in the treatment of Type 1 diabetes.