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SQI: Simpson Querry Institute

Susan E. Quaggin

  • Charles H. Mayo, MD, Professor of Medicine
  • Chief of Nephrology and Hypertension, Department of Medicine
  • Director, Feinberg Cardiovascular and Renal Research Institute
MD (1988), University of Toronto

The Quaggin lab focuses on the basic biology of vascular tyrosine kinase signaling in development and diseases of the blood and lymphatic vasculature. Our projects include uncovering the molecular mechanisms of diabetic vascular complications, thrombotic microangiopathy, glomerular diseases and glaucoma. Utilizing a combination of mouse genetic, cell biologic and proteomic approaches, we have identified key roles for Angiopoietin-Tie2 and vascular endothelial growth factor signaling in these diseases. Members of the lab are developing novel therapeutic agents that target these pathways. 

Areas of Interest

Nephrology, Hypertension, Lymphatic Vasculature in Health and Disease, Microvascular Disease

Kidney vasculature