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SQI: Simpson Querry Institute

James M. Mathew

  • Research Professor of Surgery
  • Research Professor of Microbiology-Immunology
  • Director, Immune Monitoring Core of Comprehensive Transplant Center

PhD (1988), Madurai Kamaraj University, India

Dr. Mathew’s research for the past three decades has been in the areas of immune responsiveness and tolerance in clinical organ transplantation. The major thrust has been on the immunological effects of donor bone marrow and hematopoietic stem cell infusions in transplant patients. Another key focus has been on the differential susceptibility of regulatory T cells (Tregs) to various immunosuppressive drugs currently used in clinical transplantation. More recent efforts have been on the use of polyclonally and antigen-specifically expanded autologous Tregs for tolerance induction in clinical transplantation, autoimmunity, and allergic diseases.

Dr. Mathew is now utilizing bionanotechnology to tackle the major challenges of ischemic injuries and tolerance induction in clinical transplantation together with other members of SQI and the Comprehensive Transplant Center (CTC). As the Director of the Immune Monitoring Core of the CTC, Dr. Mathew provides immune monitoring support for most of the clinical trials undertaken by the faculty members of the CTC and of many other departments at Northwestern University. In addition, he is developing biomarkers of clinical transplant immunity and tolerance.

Areas of Interest

Transplant Immunology, Autoimmunity, Transplant Tolerance, Donor Stem Cells, Regulatory T Cells, Biomarkers

Image from James Mathew's research