News and Announcements
Developing new approaches for spinal cord injury
Northwestern researchers led by SQI director Samuel Stupp have developed a molecular “scaffold” capable of enhancing electrical activity and growth in neurons, which may prove useful in treating spinal cord injuries. The scaffolds were composed of a novel nanofiber that mimics the bioactivity of the protein netrin-1 and sustainably delivers signals to neurons over long periods of time.
SQI members Evangelos Kiskinis and Zaida Alvarez were coauthors of the paper, which was published in ACS Nano.
Identifying molecular culprits underlying organ rejection
A research team including SQI member Zheng Jenny Zhang has identified how the immune system can regulate organ rejection in mice, which may prove useful for improving transplant tolerance in humans.
The findings suggest that priming T-cells of transplant recipients with repeated injections of antigens from their organ donor may help the recipient’s body avoid organ rejection resulting from infection. The results of the study also identify donor MHC class II as a problematic antigen that may be a cause of rejection after severe infections.