Upcoming Events

 

Rising Stars of SQI Seminar: Wednesday, October 24, 2018

By Sean Allen

Member of the Evan Scott Lab 

“Rapid, Sterile, and Clinical-Scale Synthesis and Directed Self-Assembly of Block Copolymers for Applications in Nanomedicine”

3:00pm: Poster Session
3:30pm: Lecture

Baldwin Auditorium

Lurie Building

303 East Superior Street

Chicago Campus

Refreshments will be provided

 

For more information, contact Alexandra Kolot: a-kolot@northwestern.edu

View flyer here

 

Abstract

Polymeric nanocarriers can be engineered to deliver small molecule drugs, peptides, proteins, and nucleic acids in a targeted fashion for biomedical applications. Despite significant potential, nanomedicine remains sparsely adopted in clinical settings. One barrier to translation has been the transition from laboratory-scale to clinical-scale synthesis and preparation of nanocarriers. Our lab has focused on both the development and application of novel drug delivery systems as well as the rapid and sterile production of large uniform batches of nanocarriers for eventual clinical use. This process, flash nanoprecipitation, has allowed us to rapidly and reproducibly produce monodisperse gram-scale nanocarrier formulations for exploring toxicity and biodistribution in both murine and non-human primate models.  I will present our recent applications of flash nanoprecipitation in nanomedicine, along with our new platforms for sustained drug release, treatment of atherosclerosis and glaucoma, and subunit vaccination.

 

Biography 

Sean Allen received his B.A. from UC Berkeley and his M.S. from San Francisco State, both in Molecular and Cell Biology, prior to joining the IBiS program and the Scott Lab at Northwestern University for his PhD in 2013. He is entering his 6th year in the program, and plans to graduate at the end of 2018. He has published 7 original research articles and 2 review articles since joining the Scott Lab, and completed an internship at Genentech as an NIH Biotechnology Training Program grant recipient.