Peptide Synthesis Core

Our Services

The Simpson Querrey Institute's Peptide Synthesis Core Facility produces custom peptides for Institute members, NU researchers, and other local academic and commercial labs.

Our facility provides customers with high quality peptides synthesized at 0.1-2mmol scales and purified by reverse-phase HPLC. We can also carry out side chain or terminal modifications such as the addition of fluorescent or biotin labels according to the customers' research applications. In addition, we utilize the leading-edge Agilent 6520 Q-TOF LCMS system to develop and deliver a wide range of mass spectrometry services.

The Peptide Synthesis Core is the proud recipient of the 2015 Outstanding Core Facility Award, received honorable mention in the 2016 Outstanding Core Facility Competition, and ranked #2 in customer satisfaction on the 2016 Core Facility Users Survey. The core is also a member of the NSF-supported SHyNE Resource.

The Peptide Synthesis Core is located on the 11th floor of the Robert H. Lurie Medical Research Center on Northwestern University's Chicago Campus.


Our Equipment

Peptide Synthesis
CEM Liberty Blue Microwave Assisted Peptide Synthesizer
CEM Liberty 12-Channel Automated Microwave Peptide Synthesizer
CS Bio CS136XT Peptide Synthesizer

Shimadzu Prominence HPLC
Waters Prep 150 HPLC
Prep HPLC full service, Prep HPLC self-service* and equipment training*
*SQI members only

Mass Spectrometry
Agilent 6520, Q-TOF LCMS
Molecular weight determination of small molecules, peptides, proteins and oligonucleotides, LCMS analysis for purity determination, proteomics study



Acknowledging the Institute's Peptide Synthesis Core Facility

Acknowledging use of the Simpson Querrey Institute's Peptide Synthesis Core in your publications is very important. Acknowledgements help us demonstrate the Core's value to the Northwestern research community and they will contribute tremendously in our efforts to secure funding for new instruments and services.

Please send full citations for your publications to the Peptide Synthesis Core Director, Mark Karver. We appreciate your support!

Here is an example acknowledgement statement you can adapt for use in your manuscripts:

[Peptide synthesis] was performed in the Peptide Synthesis Core Facility of the Simpson Querrey Institute at Northwestern University. The U.S. Army Research Office, the U.S. Army Medical Research and Materiel Command, and Northwestern University provided funding to develop this facility and ongoing support is being received from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205).

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Peptide Synthesis Core Facility Contacts

Mark Karver

Director, Peptide Synthesis Core

Suvendu Biswas

Assistant Core Scientist

Emily Ayello

Research Technologist

Todd Linton




Users must establish a NUCore account to reserve time on instruments in the Institute Cores. To set up an account, contact Alexandra Kolot (312.503.6708).

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