Skip to main content

SQI: Simpson Querry Institute

Wellington Hsu

  • Clifford C. Raisbeck, MD, Professor of Orthopaedic Surgery
  • Professor of Neurological Surgery

MD (2001), Vanderbilt University

Dr. Hsu’s clinical practice focuses on the use of minimally invasive procedures to treat spinal disorders. This includes the integration of technological advances such as image navigation, percutaneous instrumentation placement, and robotic surgery.  

The Hsu laboratory focuses on developing novel biomaterials for bone regeneration with a particular interest in spine. Dr. Hsu and his wife, molecular toxicologist Erin Hsu, study nanotechnology-based synthetic matrices, osteoinductive 3D-printable natural materials, and novel allograft material in order to provide a bone graft substitute for spinal fusion. The overarching goal is to develop translatable approaches to bone regeneration that are more effective and safer than current clinically available products.

In collaboration with the Stupp group, the Hsu lab employs bioactive self-assembling peptide amphiphile nanofiber matrices to deliver ultra-low dose growth factor or enhance the efficacy of low-volume autograft bone in pre-clinical spine fusion models. With collaborators at Dimension Inx, Dr. Hsu is also investigating novel ways to utilize 3D-printing of composite scaffolds with allograft bone and synthetic hydroxyapatite particles to lead to spinal fusion.  

Dr. Hsu also serves as the Director of Research for the Department of Orthopaedic Surgery at Northwestern Feinberg School of Medicine. He facilitates the ongoing and potential collaborations between the research scientists of the Simpson Querrey Institute and the clinicians of joint replacement, sports medicine, and hand surgery.

Key Publications

Bony Ingrowth Potential of 3D-Printed Porous Titanium Alloy: A Direct Comparison of Interbody Cage Materials in an In Vivo Ovine Lumbar Fusion Model
McGilvray, K.C.; Easley, J.; Seim, H.B.; Regan, D.; Berven, S.H.; Hsu, W.K.; Mroz, T.E.; Puttlitz, C.M.
The Spine Journal 2018, 18 (7), 1250-1260.

Sulfated Glycopeptide Nanostructures for Multipotent Protein Activation
Lee, S.S.; Fyrner, T.; Chen, F.; Álvarez, Z.; Sleep, E.; Chun, D.S.; Weiner, J.A.; Cook, R.W.; Freshman, R.D.; Schallmo, M.S.; Katchko, K.M.; Schneider, A.D.; Smith, J.T.; Yun, C.; Singh, G.; Hashmi, S.Z.; McClendon, M.T.; Yu, Z.; Stock, S.R.; Hsu, W.K.; Hsu, E.L.; Stupp, S.I. 
Nature Nanotechnology 2017, 12 (8), 821-829.

Gel Scaffolds of BMP-2-Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis
Lee, S.S.; Hsu, E.L.; Mendoza, M.; Ghodasra, J.; Nickoli, M.S.; Ashtekar, A.; Polavarapu, M.; Babu, J.; Riaz, R.M.; Nicolas, J.D.; Nelson, D.; Hashmi, S.Z.; Kaltz, S.R.; Earhart, J.S.; Merk, B.R.; McKee, J.S.; Bairstow, S.F.; Shah, R.N.; Hsu, W.K.; Stupp, S.I.
Advanced Healthcare Materials 2015, 4 (1), 131-141. 

SQI Publications

See all SQI publications authored by Wellington Hsu

VIEW PUBLICATIONS

Areas of Interest

Bone Regeneration, Spine Fusion, Osteogenesis

placeholder