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SQI: Simpson Querry Institute

Evangelos Kiskinis

  • Assistant Professor of Neurology, Division of Neuromuscular Disease
  • Assistant Professor of Physiology

PhD (2008), Imperial College London

The Kiskinis lab seeks to harness the power of pluripotent stem cells to understand how neuronal function is impaired in neurological disease. We utilize patient-specific induced pluripotent stem cells (iPSCs) and direct reprogramming to generate distinct neuronal subtypes of the central nervous system (CNS), including motor neurons, astrocytes, cortical excitatory and inhibitory neurons. We study these cells by a combination of genomic, biochemical and functional electrophysiological assays. In alignment with the mission of SQI our overall objective is to develop models of human neurological diseases by combining iPSC and bionanotechnology approaches for the therapeutic benefit of patients.

Key Publications

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
Kiskinis, E.; Kralj, J.M.; Zou, P.; Weinstein, E.N.; Zhang, H.; Tsioras, K.; Wiskow, O.; Ortega, J.A.; Eggan, K.; Cohen, A.E.
Stem Cell Reports. 2018, 10 (6), 1991-2004. 

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
Ziller, M.J.; Ortega, J.A.; Quinlan, K.A.; Santos, D.P.; Gu, H.; Martin, E.J.; Galonska, C.; Pop, R.; Maidl, S.; Di Pardo, A.; Huang, M.; Meltzer, H.Y.; Gnirke, A.; Heckman, C.J.; Meissner, A.; Kiskinis, E.
Cell Stem Cell. 2018, 22 (4), 559-574.

Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Kiskinis, E.; Sandoe, J.; Williams, L.A.; Boulting, G.L.; Moccia, R.; Wainger, B.J.; Han, S.; Peng, T.; Thams, S.; Mikkilineni, S.; Mellin, C.; Merkle, F.T.; Davis-Dusenbery, B.N.; Ziller, M.; Oakley, D.; Ichida, J.; Dicostanza, S.; Atwater, A.; Mader, M.L.; Goodwin, M.J.; Nemesh, J.; Handsaker, R.E.; Paull, D.; Noggle, S.; McCarroll, S.A.; Joung, J.K.; Woolf, C.J.; Brown, R.H.; Eggan, K.
Cell Stem Cell. 2014, 14 (6), 781-795.

Reference Maps of Human ES And iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
Bock, C.; Kiskinis, E.; Verstappen, G.; Gu, H.; Boulting, G.; Smith, Z.D.; Ziller, M.; Grinke A.; Croft, G.F.; Weygandt-Amoroso, M.; Oakley, D.H.; Eggan, K.; Meissner, A. 
Cell. 2011, 144 (3), 439-52.

SQI Publications

See all SQI publications authored by Evangelos Kiskinis


Areas of Interest

Induced Pluripotent Stem Cells (iPSCs), Modeling Neurological Disease, Nanotechnology, Neural Organoids