Research Assistant Professor, Department of Orthopaedic Surgery
PhD (2007) University of California-Los Angeles
Associate Professor, Department of Orthopaedic Surgery
Clifford C. Raisbeck, MD, Professor of Orthopaedic Surgery
MD (2001) Vanderbilt University
The research team led by molecular toxicologist Erin Hsu and orthopaedic surgeon Wellington Hsu focuses on developing novel biomaterials for bone regeneration. The approaches and technologies they utilize include stem cell-based therapies, nanotechnology-based synthetic matrices, and osteoinductive 3D-printable natural and synthetic materials. In these endeavors, they have forged strong collaborative relationships with SQI faculty, including Samuel Stupp and Ramille Shah.
With a particular interest in spine, an overarching goal of the Hsu laboratory is to develop translatable approaches to bone regeneration and spine fusion that are more effective and safer than current clinically available products. With the Stupp group, they employ bioactive self-assembling peptide amphiphile nanofiber matrices as a means of delivering ultra-low dose growth factor or enhancing the efficacy of low-volume autograft bone in pre-clinical spine fusion animal models. They are also exploring the utility of these nanofiber matrices in the delivery of stem cell aggregates and induced pluripotent stem cells in the spine fusion and craniofacial settings.
With the Shah group, the Hsu lab is developing 3D-printed hyperelastic composite scaffolds for bone regeneration that are composed of allograft bone (demineralized bone matrix) and synthetic hydroxyapatite particles. Using a similar strategy, they are also developing scaffolds with the ability to simultaneously deliver local antibiotics and osteoinductive small molecules, to promote healing of large segmental defects after extremity trauma while preventing infection by multidrug-resistant organisms.